
Cassiopeia Build
the Serpent's Embrace
Cassiopeia is a deadly creature bent on manipulating others to her sinister will. Youngest and most beautiful daughter of the noble Du Couteau family of Noxus, she ventured deep into the crypts beneath Shurima in search of ancient power. There, she was bitten by a gruesome tomb guardian, whose venom transformed her into a viper-like predator. Cunning and agile, Cassiopeia now slithers under the veil of night, petrifying her enemies with her baleful gaze.
The most played Cassiopeia Mid build on patch 26.21 runs Deathfire Touch with Manaflow Band, Transcendence and Scorch, plus Coup de Grace and Presence of Mind from the secondary tree. Take Flash and Teleport. Start with Doran's Ring and Health Potion, then build Rod of Ages, Swiftmarch and Seraph's Embrace, followed by Rylai's Crystal Scepter, Zhonya's Hourglass and Rabadon's Deathcap. Max E (Twin Fang) first, then Q (Noxious Blast), then W (Miasma). It has a 48.1% win rate and a 1.1% pick rate.
Runes
Primary
Deathfire Touch
Damaging a champion with an ability burns them over time.
Deathfire Touch
Damaging a champion with an ability burns them for 3 - 12 based on level (+2.5% AP) (+7% bonus AD) magic damage per second. After burning for 3 seconds, the damage of the burn increases by 75% while they remain on fire. Duration: Single Target: 4s Area of Effect: 2s Damage over Time: 1s
Manaflow Band
Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana. After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds.
Manaflow Band
Hitting an enemy champion with an ability permanently increases your maximum mana by 25, up to 250 mana. After reaching 250 bonus mana, restore 1% of your missing mana every 5 seconds. Cooldown: 15 seconds
Transcendence
Gain bonuses upon reaching the following levels: Level 5: +5 Ability Haste Level 8: +5 Ability Haste Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.
Transcendence
Gain bonuses upon reaching the following levels: Level 5: +5 Ability Haste Level 8: +5 Ability Haste Level 11: On Champion takedown, reduce the remaining cooldown of basic abilities by 20%.
Scorch
Your first damaging ability hit every 10s burns champions.
Scorch
Your next damaging ability hit sets champions on fire dealing 20 - 40 bonus magic damage based on level after 1s. Cooldown: 10s
Secondary
Coup de Grace
Deal more damage to low health enemy champions.
Coup de Grace
Deal 8% more damage to champions who have less than 40% health.
Presence of Mind
Restore a small amount of mana or energy when damaging an enemy champion. Takedowns restore mana or energy.
Presence of Mind
Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy. Takedowns restore 15% of your maximum mana or energy. Cooldown for damage restoration: 8s
Summoner Spells
Flash
Cooldown 300s
Flash
Cooldown 300s
Teleports you a short distance toward your cursor.
Teleport
Cooldown 300s
Teleport
Cooldown 300s
After a brief channel, become untargetable and travel to an allied unit. Upgrades into Unleashed Teleport, which significantly increases travel speed.
Skill Priority
ETwin Fang
Cooldown 0.75s · 45 Mana
Cassiopeia lets loose an attack that deals increased damage to Poisoned targets and heals her for a percentage of the damage dealt. If the target dies from this attack, Cassiopeia regains Mana.
QNoxious Blast
Cooldown 3.5s · 50/55/60/65/70 Mana
Cassiopeia blasts an area with Poison after a brief delay, granting her increased Move Speed if she hits an enemy champion.
WMiasma
Cooldown 24/22/20/18/16s · 70/75/80/85/90 Mana
Cassiopeia releases several clouds of poison, slowing, grounding, and lightly damaging enemies that pass through them. Grounded enemies cannot use Movement abilities.
Item Build
Full build 15,850gStarting Items
Doran's Ring
400g
Doran's Ring
- 18 Ability Power
- 90 Health
Drain Restore 1 Mana every second, increased to 2 Mana per second for 5 seconds after dealing damage to an enemy champion. If you can't gain Mana, heal for 45% of this value instead. Helping Hand Attacks deal 5 bonus physical damage to minions.
Health Potion
2 × 50g
Health Potion
Consume Restores 120 Health over 15 seconds.
Core Build
1Rod of Ages
2,600g45 AP · 350 HP · 500 Mana
Timeless · Eternity
Rod of Ages
2,600g- 45 Ability Power
- 350 Health
- 500 Mana
Timeless This item gains 10 Health, 30 Mana and 3 Ability Power every 60 seconds up to 10 times. Upon reaching max stacks, gain a level. Eternity Taking damage from champions restores 10% of the damage as Mana. Casting an ability heals for 25% of Mana spent.
2Swiftmarch
1,000g65 MS
Fleetfooted · Noxian Fervor
Swiftmarch
1,000g- 65 Move Speed
Fleetfooted Reduce the effectiveness of Slows by 25%. Noxian Fervor Gain 5% of your Move Speed as Adaptive Force.
3Seraph's Embrace
2,900g70 AP · 1000 Mana · 25 AH
Awe · Lifeline
Seraph's Embrace
2,900g- 70 Ability Power
- 1000 Mana
- 25 Ability Haste
Awe Gain Ability Power. Lifeline (0s) Taking damage that would reduce your Health below 30% grants a Shield for 3 seconds.
4Rylai's Crystal Scepter
2,600g65 AP · 400 HP
Rimefrost
Rylai's Crystal Scepter
2,600g- 65 Ability Power
- 400 Health
Rimefrost Damaging Abilities Slow enemies by 30% for 1 second.
5Zhonya's Hourglass
3,250g105 AP · 50 Armor
Time Stop
Zhonya's Hourglass
3,250g- 105 Ability Power
- 50 Armor
Time Stop Enter Stasis for 2.5 seconds.
6Rabadon's Deathcap
3,500g130 AP
Magical Opus
Rabadon's Deathcap
3,500g- 130 Ability Power
Magical Opus Increases your total Ability Power by 30%.
Abilities & Skill Path

Serpentine Grace
All Move Speed bonuses are more effective on Cassiopeia.
QNoxious Blast
Cooldown 3.5s · 50/55/60/65/70 Mana
Cassiopeia blasts an area with Poison after a brief delay, granting her increased Move Speed if she hits an enemy champion.
WMiasma
Cooldown 24/22/20/18/16s · 70/75/80/85/90 Mana
Cassiopeia releases several clouds of poison, slowing, grounding, and lightly damaging enemies that pass through them. Grounded enemies cannot use Movement abilities.
ETwin Fang
Cooldown 0.75s · 45 Mana
Cassiopeia lets loose an attack that deals increased damage to Poisoned targets and heals her for a percentage of the damage dealt. If the target dies from this attack, Cassiopeia regains Mana.
RPetrifying Gaze
Cooldown 120/100/80s · 100 Mana
Cassiopeia releases a swirl of magical energy from her eyes, stunning any enemies in front of her that are facing her and slowing any others with their back turned.